Mississippi Pot Roast Meatloaf Recipe
Introduction
This Mississippi Pot Roast Meatloaf is a flavorful twist on classic comfort food, combining the tangy kick of pepperoncinis with savory ranch seasoning. It’s easy to prepare and perfect for a hearty family dinner.

Ingredients
- 2 pounds ground beef (85/15 or 90/10)
- 1/2 cup roughly chopped pepperoncinis
- 1 cup plain bread crumbs
- 1/4 cup pepperoncini juice
- 1 large egg
- 2 tablespoons Worcestershire sauce
- 2 tablespoons dry ranch seasoning
- 2 cups beef broth (divided)
- 1/4 cup pepperoncini juices (additional)
- 1 teaspoon Worcestershire sauce (additional)
- 1/2 cup water
- 1/4 cup cornstarch
Instructions
- Step 1: Preheat the oven to 350°F (175°C). Lightly grease a 9×13-inch baking pan.
- Step 2: In a large mixing bowl, combine ground beef, chopped pepperoncinis, bread crumbs, pepperoncini juice, egg, Worcestershire sauce, and dry ranch seasoning. Mix gently with your hands until just combined.
- Step 3: Shape the mixture into a loaf and place it in the prepared baking pan.
- Step 4: In a small bowl, whisk together 1 cup beef broth, dry ranch seasoning, additional pepperoncini juices, and Worcestershire sauce. Pour this mixture evenly over the meatloaf. Optionally, arrange extra pepperoncini slices on top for garnish.
- Step 5: Bake for 60 minutes, or until the internal temperature reaches 160°F (71°C).
- Step 6: Remove the pan carefully and strain the drippings into a bowl. Skim off excess grease if necessary.
- Step 7: To make the gravy, whisk the remaining beef broth, water, and cornstarch in a small bowl to form a slurry. In a medium saucepan, combine the reserved drippings with the slurry. Cook over medium heat, stirring constantly, until the gravy thickens and simmers.
- Step 8: Slice the meatloaf and serve hot, drizzled with gravy. It pairs well with mashed potatoes or egg noodles.
Tips & Variations
- For added moisture, consider mixing a little milk into the bread crumbs before combining with the beef.
- Use a meat thermometer to ensure the meatloaf reaches the safe internal temperature without overcooking.
- Swap ground beef for a mix of beef and pork for a richer flavor.
- If you prefer less tang, reduce the amount of pepperoncinis or their juice slightly.
Storage
Store leftover meatloaf and gravy in an airtight container in the refrigerator for up to 3 days. Reheat gently in the microwave or oven until warmed through. You can also freeze the cooked meatloaf for up to 3 months; thaw overnight in the fridge before reheating.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I make this meatloaf ahead of time?
Yes, you can assemble the meatloaf and keep it covered in the refrigerator for a few hours before baking. This can help the flavors meld and make dinner prep easier.
What if I don’t have pepperoncinis accessible?
You can substitute mild banana peppers or pickled jalapeños for a similar tangy, slightly spicy flavor, though the taste will vary slightly.
PrintMississippi Pot Roast Meatloaf Recipe
This Mississippi Pot Roast Meatloaf is a flavorful twist on a classic comfort food, infusing the savory beef with tangy pepperoncinis, ranch seasoning, and Worcestershire sauce. Baked to perfection and served with a rich, homemade gravy made from the pan drippings, it offers a hearty and satisfying meal perfect for family dinners.
- Prep Time: 15 minutes
- Cook Time: 60 minutes
- Total Time: 1 hour 15 minutes
- Yield: 8 servings 1x
- Category: Main Course
- Method: Baking
- Cuisine: American
Ingredients
Meatloaf
- 2 pounds ground beef (85/15 or 90/10)
- 1/2 cup roughly chopped pepperoncinis
- 1 cup plain bread crumbs
- 1/4 cup pepperoncini juice
- 1 large egg
- 2 tablespoons Worcestershire sauce
- 2 tablespoons dry ranch seasoning
Gravy
- 2 cups beef broth (divided)
- 2 tablespoons dry ranch seasoning
- 1/4 cup pepperoncini juices
- 1 teaspoon Worcestershire sauce
- 1/2 cup water
- 1/4 cup cornstarch
Instructions
- Preheat and prepare pan: Preheat the oven to 350°F (175°C) and lightly grease a 9×13-inch baking pan.
- Mix meatloaf ingredients: In a large bowl, gently combine ground beef, chopped pepperoncinis, bread crumbs, pepperoncini juice, egg, Worcestershire sauce, and dry ranch seasoning using your hands until just mixed.
- Shape and place in pan: Form the mixture into a loaf shape and place it in the prepared baking pan.
- Prepare topping mixture: Whisk together 1 cup beef broth, ranch seasoning, pepperoncini juices, and Worcestershire sauce in a small bowl. Pour evenly over the meatloaf and optionally top with extra pepperoncini slices.
- Bake: Bake the meatloaf for 60 minutes, or until the internal temperature reaches 160°F (71°C).
- Remove drippings: Carefully take the pan out of the oven, strain the drippings into a bowl, and skim off any excess grease.
- Make gravy: In a small bowl, whisk remaining 1 cup beef broth, water, and cornstarch to make a slurry. In a saucepan, combine the drippings and slurry; cook over medium heat, stirring constantly until thickened into gravy.
- Serve: Slice the meatloaf and serve hot with mashed potatoes or egg noodles, drizzling the gravy on top.
Notes
- Ensure the meatloaf reaches an internal temperature of 160°F for safe consumption.
- You can garnish with extra pepperoncini slices for added tang and presentation.
- Using lean ground beef (85/15 or 90/10) helps reduce excess grease in the meatloaf.
- For a gluten-free version, use gluten-free bread crumbs.
- This meatloaf pairs wonderfully with creamy mashed potatoes or buttered egg noodles.
Keywords: Mississippi Pot Roast Meatloaf, meatloaf recipe, pepperoncini meatloaf, ranch seasoning meatloaf, comfort food, baked meatloaf, easy meatloaf recipe

