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Mississippi Pot Roast Meatloaf Recipe

4.4 from 515 reviews

This Mississippi Pot Roast Meatloaf is a flavorful twist on a classic comfort food, infusing the savory beef with tangy pepperoncinis, ranch seasoning, and Worcestershire sauce. Baked to perfection and served with a rich, homemade gravy made from the pan drippings, it offers a hearty and satisfying meal perfect for family dinners.

Ingredients

Scale

Meatloaf

  • 2 pounds ground beef (85/15 or 90/10)
  • 1/2 cup roughly chopped pepperoncinis
  • 1 cup plain bread crumbs
  • 1/4 cup pepperoncini juice
  • 1 large egg
  • 2 tablespoons Worcestershire sauce
  • 2 tablespoons dry ranch seasoning

Gravy

  • 2 cups beef broth (divided)
  • 2 tablespoons dry ranch seasoning
  • 1/4 cup pepperoncini juices
  • 1 teaspoon Worcestershire sauce
  • 1/2 cup water
  • 1/4 cup cornstarch

Instructions

  1. Preheat and prepare pan: Preheat the oven to 350°F (175°C) and lightly grease a 9×13-inch baking pan.
  2. Mix meatloaf ingredients: In a large bowl, gently combine ground beef, chopped pepperoncinis, bread crumbs, pepperoncini juice, egg, Worcestershire sauce, and dry ranch seasoning using your hands until just mixed.
  3. Shape and place in pan: Form the mixture into a loaf shape and place it in the prepared baking pan.
  4. Prepare topping mixture: Whisk together 1 cup beef broth, ranch seasoning, pepperoncini juices, and Worcestershire sauce in a small bowl. Pour evenly over the meatloaf and optionally top with extra pepperoncini slices.
  5. Bake: Bake the meatloaf for 60 minutes, or until the internal temperature reaches 160°F (71°C).
  6. Remove drippings: Carefully take the pan out of the oven, strain the drippings into a bowl, and skim off any excess grease.
  7. Make gravy: In a small bowl, whisk remaining 1 cup beef broth, water, and cornstarch to make a slurry. In a saucepan, combine the drippings and slurry; cook over medium heat, stirring constantly until thickened into gravy.
  8. Serve: Slice the meatloaf and serve hot with mashed potatoes or egg noodles, drizzling the gravy on top.

Notes

  • Ensure the meatloaf reaches an internal temperature of 160°F for safe consumption.
  • You can garnish with extra pepperoncini slices for added tang and presentation.
  • Using lean ground beef (85/15 or 90/10) helps reduce excess grease in the meatloaf.
  • For a gluten-free version, use gluten-free bread crumbs.
  • This meatloaf pairs wonderfully with creamy mashed potatoes or buttered egg noodles.

Keywords: Mississippi Pot Roast Meatloaf, meatloaf recipe, pepperoncini meatloaf, ranch seasoning meatloaf, comfort food, baked meatloaf, easy meatloaf recipe